Pelvilen and resveratrol: a double clutch against pain and inflammation
In Pelvilen two natural painkillers and inhibitors of inflammation are combined: palmitoylethanolamide and a resveratrol, polydatin. On this website enough information about the preclinical and clinical data supporting the use of palmitoylethanolamide in various painstates. Here we shortly focus on the resveratrol.
About the latter the following:
"Resveratrol, a naturally occurring polyphenol found mainly in red wine, grapes and berries, has been shown to have many therapeutic values. It is known to protect against heart disease and cancers, promote anti-aging effects, suppress neuronal degeneration and also act as an analgesic. Earlier studies indicated that intra-peritoneal administration of resveratrol decreases hyperalgesia in the rat model of inflammatory pain, which was induced by carrageenan injection in the hind paw, and this was attributed to the previously reported inhibitory effects of resveratrol on cyclooxygenase (COX)-2 expression. Intra-cerebral injections of resveratrol also suppressed hyperalgesia in the rat model of thermal pain with a concomitant inhibition of COX-1 and COX-2. Similar analgesic effects of resveratrol were also observed in the rat model of diabetic neuropathic pain."